Abstract
Purpose: Treatment of hypovascular tumors, such as pancreatic adenocarcinoma, is challenging owing to inefficient drug delivery. This report examines the potential mechanism of localized drug delivery via transarterial microperfusion (TAMP) using a proprietary adjustable double-balloon occlusion catheter in a porcine model.
Materials and methods: Adult Yorkshire swine (N = 21) were used in the Institutional Animal Care & Use Committee-approved protocols. The RC-120 catheter (RenovoRx, Los Altos, California) was positioned into visceral, femoral, and pulmonary arteries with infusion of methylene blue dye, gemcitabine, or gold nanoparticles. Transmural delivery was compared under double-balloon occlusion with and without side-branch exclusion, single-balloon occlusion, and intravenous delivery. Intra-arterial pressure and vascular histologic changes were assessed.
Results: Infusion with double-balloon occlusion and side-branch exclusion provided increased intra-arterial pressure in the isolated segment and enhanced perivascular infusate penetration with minimal vascular injury. Infusates were predominantly found in the vasa vasorum by electron microscopy.
Conclusions: TAMP enhanced transmural passage mediated by localized increase in arterial pressure via vasa vasorum.
Publication Date
7-1-2024
Content Type
Article
PubMed ID:
Citation
Farsad, K., Novelli, P. M., Laing, C., Gandhi, R. T., Cynamon, J., López, C. S., Stempinski, E. S., Strasser, R., & Agah, R. (2024). Double-Balloon Catheter-Mediated Transarterial Chemotherapy Delivery in a Swine Model: A Mechanism Recruiting the Vasa Vasorum for Localized Therapies. Journal of vascular and interventional radiology : JVIR, 35(7), 1043–1048.e3. https://doi.org/10.1016/j.jvir.2024.03.016
Comments
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